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The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

Identifieur interne : 000085 ( Main/Exploration ); précédent : 000084; suivant : 000086

The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

Auteurs : Bouchra Qaddouri [Maroc] ; Abdelkarim Guaadaoui [Maroc] ; Ahmed Bellirou [Maroc] ; Abdellah Hamal [Maroc] ; Ahmed Melhaoui [Maroc] ; Grant W. Brown ; Mohammed Bellaoui

Source :

RBID : PMC:3139508

Abstract

The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.


Url:
DOI: 10.1093/ecam/nep069
PubMed: 19596744
PubMed Central: 3139508


Affiliations:


Links toward previous steps (curation, corpus...)


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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19596744" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MaghrebDataLibMedV2 

Wicri

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Data generation: Wed Jun 30 18:27:05 2021. Site generation: Wed Jun 30 18:34:21 2021