The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties
Identifieur interne : 000085 ( Main/Exploration ); précédent : 000084; suivant : 000086The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties
Auteurs : Bouchra Qaddouri [Maroc] ; Abdelkarim Guaadaoui [Maroc] ; Ahmed Bellirou [Maroc] ; Abdellah Hamal [Maroc] ; Ahmed Melhaoui [Maroc] ; Grant W. Brown ; Mohammed BellaouiSource :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2011.
Abstract
The budding yeast
Url:
DOI: 10.1093/ecam/nep069
PubMed: 19596744
PubMed Central: 3139508
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Budding Yeast “<italic>Saccharomyces cerevisiae</italic>
” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties</title>
<author><name sortKey="Qaddouri, Bouchra" sort="Qaddouri, Bouchra" uniqKey="Qaddouri B" first="Bouchra" last="Qaddouri">Bouchra Qaddouri</name>
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<wicri:regionArea>Laboratoire de Génétique et Biotechnologies, Faculté des Sciences, Université Mohamed Premier, Oujda 60000</wicri:regionArea>
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<author><name sortKey="Guaadaoui, Abdelkarim" sort="Guaadaoui, Abdelkarim" uniqKey="Guaadaoui A" first="Abdelkarim" last="Guaadaoui">Abdelkarim Guaadaoui</name>
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<series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title>
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<front><div type="abstract" xml:lang="en"><p>The budding yeast <italic>Saccharomyces cerevisiae</italic>
is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.</p>
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